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IMMUNOGLOBULIN FAB FRAGMENTS
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DeCS
Descriptor
English
:
Immunoglobulin Fab Fragments
Descriptor
Spanish
:
Fragmentos Fab de Inmunoglobulinas
Descriptor
Portuguese
:
Fragmentos Fab das Imunoglobulinas
Synonyms
English
:
Fab Fragments
Immunoglobulins, Fab Fragment
Tree Number:
D12.644.541.500.650
D12.776.124.486.485.680.650
D12.776.124.790.651.680.650
D12.776.377.715.548.680.650
Definition
English
:
Univalent antigen-binding fragments composed of one entire IMMUNOGLOBULIN LIGHT CHAIN and the amino terminal end of one of the
IMMUNOGLOBULIN HEAVY CHAINS
from the hinge region, linked to each other by disulfide bonds. Fab contains the IMMUNOGLOBULIN VARIABLE REGIONS, which are part of the antigen-binding site, and the first
IMMUNOGLOBULIN CONSTANT REGIONS
. This fragment can be obtained by
digestion
of
immunoglobulins
with the proteolytic enzyme
PAPAIN.
Indexing Annotation
English
:
DF: IG FAB
Pharmacological Action:
Immunologic Factors
History Note
English
:
2006 (1973)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CH
chemistry
CL
classification
CT
contraindications
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
22214
Unique Identifier:
D007140
Occurrence in VHL
:
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